ABSTRACT
Objective: We aimed to evaluate the relationship between /L-6-174G>C, -572G>C and -597G>A polymorphisms and development of coronary artery diseases in a Chinese population. Methods: A total of 275 patients with coronary artery disease and 296 healthy control subjects were collected between January 2013 and November 2014. The IL-6 genotyping for -174G>C, -592G>C and -597G>A polymorphic sites was determined by polymerase chain reaction-restriction fragment length polymorphism [PCR-RFLP] according to the manufacturer instructions
Results: Using unconditional regression analysis, we observed that the AC and CC genotypes of IL-6 -592A>C were associated with the increased risk of developing coronary artery disease when compared with the AA genotype, and the adjusted ORs [95%CI] were 1.63[1.12-2.38] and 2.70[1.57-4.67], respectively. Additionally, the C allele of IL-6 -592A>C [OR=1.65, 95%CI=1.29-2.11] was correlated with a higher risk of developing coronary artery disease in comparison to the A allele. However, no relationship was found between /L-6-174G>C and -597G>A polymorphisms and coronary artery disease susceptibility
Conclusion: This study suggests that IL-6 -592G>C polymorphism is correlated with the risk of coronary artery disease. More well-designed prospective studies based on large sample size, multiple SNPs or haplotypes are required to confirm the current findings